2012 May;26(5):627-35.

Silvestro L, Savu SR, Savu SN, Tudoroniu A, Tarcomnicu I. Development of a sensitive method for simultaneous determination of fluticasone propionate and salmeterol in plasma samples by liquid chromatography-tandem mass spectrometry. Biomed Chromatogr. 2012 May;26(5):627-35.

PK STUDIES:

– DRUG INTERACTIONS
– DOSE FINDING
– AGE & GENDER
– SPECIAL POPULATIONS
– BIOAVAILABILITY
– BIOEQUIVALENCE

Pk/PD studies in selected populations:

– ASTHMATIC PATIENTS (INHALERS BASED ON PK STUDIES)
– COPD PATIENTS
– ELDERLY
– HORMONAL DEFICIENCIES

Derma pharmacokinetic and tolerance studies other locally acting product studies (ex. orlistat) clinical trials phase I – IV

PK/PD studies in healty volunteers; capabilities to work with big number of volunteers (200 volunteers per one study) if required

Different dosage form:

– ORAL TABLETS
– ODT
– SYRUP
– SUSPENSION_- LOZANGE
– SUPPOSITORY
– INHALANTS
– TRANSDERMAL SYSTEMS
(PATCHES / PLASTERS)
– ETC.